New research suggests that people who stop using popular slimming jabs like Mounjaro or Wegovy can put back on shed pounds at a significantly accelerated pace than those who halt conventional lifestyle regimens.
Published data in a prominent medical journal demonstrates that while obese individuals can lose about a fifth of their total mass while on the medication, the weight returns at an estimated rate of 0.8 kg per month once they quit.
"Individuals using such medications need to be cognizant of the potential of quick rebound weight gain when the medication is stopped," warns expert Dr. Susan Jebb.
That rate of regain implies a return to original weight in about 18 months.
Comparing Approaches
The research, which examined 37 of trials involving thousands of patients, contrasted the results of the injectable medications with conventional dieting.
Scientists point out that people who lose weight through lifestyle changes alone usually experience a less rapid creep back—around 0.1 kg a month—after stopping.
Explaining the Fast Regain
Doctors propose the mechanism of the injections explains the amplified regain.
These medications mimic a natural hormone called GLP-1, which helps regulate feelings of fullness.
"Artificially providing GLP-1 levels several times higher than normal may cause the system to generate a reduced amount of its endogenous hormone, and may also reduce sensitivity to its effects," noted Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this GLP-1 'fix' leads to appetite is unsuppressed, making binge eating a significant risk."
A Chronic Condition?
Health authorities recommend the jabs for people with weight-linked health risks, accompanied by prescribed lifestyle changes.
A number of clinicians contend that, given the likelihood of weight regain, the treatment should be considered life-long.
This perspective is supported by drug manufacturers, who state that the results "underscore the long-term nature of excess weight," similar to managing conditions like diabetes.
User Accounts
Individuals who have stopped the medication explain a sudden return of hunger.
"It was like a switch that goes on and you become starving," said an individual.
This difficulty is compounded if patients have not adopted sustainable lifestyle or habit modifications during treatment.
Significant Adoption
Figures suggest that a significant number of people in the UK have used these injections in the past year, with desire being substantial.
- Use is greater among females than men.
- The 40s and 50s demographic shows the greatest usage rates.
- Many access the drugs through private prescriptions rather than public health services.
Finally, researchers stress that while GLP-1 drugs are effective tools for shedding pounds, they are not a magic cure and maintained weight loss hinges on integrated lifestyle support.
